Numerical study for a model of tumor virotherapy

In this paper, we present a computational mathematical model to investigate the efficacy of tumor virotherapy using oncolytic viruses. A numerical algorithm, which is stable and second-order accurate, is developed to compute the growth of the tumor. Results from the numerical simulation have matched the experimental measurements, and validated the significance of the oncolytic viral therapy. Moreover, our numerical results suggest that this therapy can be further improved by increasing the burst size of viruses and using cyclophosphamide (CPA) treatments. 2007 Elsevier Inc. All rights reserved.